Developed for women undergoing assisted reproductive technologies (ART)

• First progesterone approved for use during ART by the US Food and Drug Administration
• Proven effective in numerous studies over 10 years

Designed to put progesterone right where you need it

• Made of a unique bioadhesive gel that coats and adheres to the vaginal walls after application to minimize leakage — No other progesterone offers this distinct,
  patient-friendly delivery method
• Progesterone in Crinone travels directly to the uterus—where it is needed
• After Crinone is absorbed, it is common and not harmful to have some gel residue buildup in the vagina

Once-daily Crinone fits easily into your morning routine

• One quick dose each morning makes it easy for you to get up, get your Crinone, and get on with your day
• Morning dosing is best because daily activity helps Crinone coat the vagina, reducing accumulation

Spotting and/or bleeding

• Similar to other progesterones, spotting and/or bleeding is possible with Crinone
• Spotting and/or bleeding is not a sign that you are not pregnant or that you have had a miscarriage. Continue to take Crinone
• If you become concerned, speak to your doctor

Crinone 8% (progesterone gel) is indicated for progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency.

IMPORTANT SAFETY INFORMATION
The most common side effects of Crinone 8% include breast enlargement, constipation, somnolence, nausea, headache, and perineal pain. Crinone 8% is contraindicated in patients with active thrombophlebitis or thromboembolic disorders, or a history of hormone-associated thrombophlebitis or thromboembolic disorders, missed abortion, undiagnosed vaginal bleeding, liver dysfunction or disease, and known or suspected malignancy of the breast or genital organs.

More information on Crinone 8%:

Crinone 8% Patient Information